Antidiabetic Sterols from Peniocereus greggii Roots.

Muñoz-Gómez RJ et al (2022).

ACS Omega.

DOI:

10.1021/acsomega.2c00595

PubMed:

35474764

Canthin-6-one (CO) from Picrasma quassioides (D.Don) Benn. ameliorates lipopolysaccharide (LPS)-induced astrocyte activation and associated brain endothelial disruption.

Canthin-6-one (CO) is a compound found in PQ that has anti-inflammatory properties. PQ has been shown to be neuroprotective, but the effects on astrocytes are unknown. Astrocytes are important in regulating neuroinflammatory responses in the CNS. Inflammatory astrocytes can cause BBB breakdown, which contributes to ND.

Yue Q et al (2022).

Phytomedicine.

DOI:

10.1016/j.phymed.2022.154108

PubMed:

35472694

Selenium-containing polysaccharides isolated from Rosa laevigata Michx fruits exhibit excellent anti-oxidant and neuroprotective activity in vitro.

Researchers isolated two new types of selenium-containing polysaccharides from the fruits of Rosa laevigata Michx. These polysaccharides were able to protect cells from oxidative damage and had a radical scavenging effect, suggesting they have potential as a treatment for neurodegenerative diseases or as a dietary supplement. The underlying mechanism of action may be related to the Nrf2/HO-1 signaling pathway.

Liu X et al (2022).

Int J Biol Macromol.

DOI:

10.1016/j.ijbiomac.2022.04.146

PubMed:

35472363

Identification of potential bioactive natural compounds from Indonesian medicinal plants against 3-chymotrypsin-like protease (3CL(pro)) of SARS-CoV-2: molecular docking, ADME/T, molecular dynamic simulations, and DFT analysis.

Researchers conducted virtual screening of 49 bioactive phytochemicals from 20 medicinal plants used in Indonesian traditional medicine and the 3CL inhibitor N3 to identify effective drugs against the SARS-CoV-2 virus. 11 compounds showed good binding affinity against the virus, and Luteolin and Naringenin showed significant interactions with the catalytic residues of the virus and displayed drug-like characteristics. Further molecular dynamics simulations and density-functional theory calculations suggest that these phytochemicals could be potential antagonists of 3CL of SARS-CoV-2.

Prasetyo WE et al (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2022.2068071

PubMed:

35470785

Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer.

Wei Y et al (2022).

Eur J Pharmacol.

DOI:

10.1016/j.ejphar.2022.174970

PubMed:

35469839

Antihyperglycemic and antidyslipidemic effects of Artemisia arborescens aqueous extract in streptozotocin-induced diabetic rat.

Azzane A, Farid O and Eddouks M (2022).

Cardiovasc Hematol Agents Med Chem.

DOI:

10.2174/1871525720666220425094135

PubMed:

35469581

Ligustrazine alleviates psoriasis-like inflammation through inhibiting TRAF6/c-JUN/NFκB signaling pathway in keratinocyte.

Jiang R et al (2022).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2022.113010

PubMed:

35468584

Isolation and elucidation of two isoflavonoids from an American Indian plant, Amorpha canescens Pursh, using Magnetic Microbead Affinity Selection Screening (MagMASS) for estrogen receptor alpha ligands.

Burton TCJ et al (2021).

Phytochem Lett.

DOI:

10.1016/j.phytol.2021.07.018

PubMed:

35465454