Sesquiterpenoids from the rhizomes of Homalomena pendula and their anti-inflammatory activities.
- Nguyen LTK et al (2023).
- Nat Prod Res.
- PubMed:
- 35337228
A study investigated the binding of oil (AGO) and its compounds to GABA receptors in rat cortical membranes and computational modeling. Results show that AGO and methyl eugenol modulate GABA receptors, suggesting their anesthetic activity in mammals is associated with GABA receptor modulation. An oil-in-water nanoemulsion containing 20% w/w AGO (NE-AGO) was formulated and showed promising potential for human anesthesia with increased specific [H]muscimol binding and high tolerance by normal human cells.