Undescribed ecdysteroids and phenolic glycosides from the roots of Cyathula officinalis Kuan and their anti-inflammatory activity in LPS-induced RAW 264.7 macrophages in vitro.
- Yang LF et al (2022).
- Phytochemistry.
- PubMed:
- 35065449
Researchers investigated the ability of the CO extract Ze 339, isopetasin, and neopetasin to inhibit the replication of the original Wuhan strain and the Delta variant of SARS-CoV-2. They found that pre-treatment with Ze 339 significantly inhibited virus replication in infected cells with IC values of 0.10 and 0.40 μg/mL, respectively. Isopetasin also showed antiviral activity with IC values ranging from 0.37 to 0.88 μM for both virus variants. In vitro results indicate the potential for Ze 339 and isopetasin as an effective treatment for SARS-CoV-2 infections, but further clinical studies are needed.