Genomic Analyses of Rose Crown Gall-Associated Bacteria Revealed Two New Agrobacterium Species: Agrobacterium burrii sp. nov. and Agrobacterium shirazense sp. nov.
- Mafakheri H et al (2022).
- Phytopathology.
- PubMed:
- 34856816
This study looks at a plant called D.Don DC, which has traditionally been used to treat neurological disorders, and its potential as a drug candidate for Alzheimer's disease (AD). Using computational drug discovery techniques, the study found that certain pyranocoumarins from the plant, such as dihydrojatamansin and jatamansinol, could be potential drug candidates for AD. The study also found that dihydrojatamansin inhibits acetylcholinesterase, while jatamansinol inhibits other AD therapeutic targets. These findings could lead to new treatments for AD.
Researchers screened a library of phytochemicals for their potential to inhibit the binding of ACE2 receptors to the spike protein of SARS-CoV-2. Out of 686 compounds, 20 were found to bind with energy ranging from -11.8 to -6.9 kcal/mol. Four compounds were found to be non-toxic and stable in molecular dynamics simulations and may prevent SARS-CoV-2 infection by inhibiting viral entry into host cells. These compounds are Hinokinin, Gmelanone, Isocolumbin, and Tinocordioside.