Cyanogenesis in Aralia spinosa (Araliaceae).
- Lechtenberg M et al (2022).
- Planta Med.
- DOI:
- 10.1055/a-1671-5525
- PubMed:
- 34784621
Researchers studied the effect of water extracts from the herbal medicine Blume (GE) on G2019S-induced Parkinson's disease (PD) in flies and mice. The study found that treatment with GE improved locomotion and protected dopaminergic neurons. GE suppressed the hyperactivation of G2019S proteins in dopaminergic neurons and activated the antioxidation and detoxification factor Nrf2 mainly in astrocyte-like and ensheathing glia. This glial activation antagonized G2019S-induced Mad/Smad signaling and prevented locomotion defects and neuronal loss in transgenic mice. These findings may offer a potential therapeutic avenue for PD.