Transcriptomic analysis reveals candidate genes for male sterility in Prunus sibirica.
- Chen J et al (2021).
- PeerJ.
- DOI:
- 10.7717/peerj.12349
- PubMed:
- 34722001
This study evaluated the potential of Mentha longifolia (MML) to protect against kidney damage caused by serotonin-induced hypoglycemia in diabetic rats. Serotonin treatment caused hypoglycemia, impaired the body's defense system, and caused abnormal kidney histopathology. However, treatment with MML extract rescued these changes and reduced the associated toxicity. The study suggests that using MML may be a useful treatment for preventing kidney damage in diabetic patients.
This study looked at the effects of consuming red raspberry extract during pregnancy in mice. High doses led to shorter gestation, smaller litter size, and other changes in offspring.
Rhodiola sacra is a component with many medicinal uses, including anti-oxidation and anti-inflammation. Researchers investigated its neuroprotective effects against transient global cerebral ischemia (tGCI) in male rats. They found that pretreatment or/and post-treatment significantly reduced neuronal injury, inhibited glial activation, and improved cognitive function. Molecular docking showed that Rhodiola sacra targets adenosine monophosphate-activated protein kinase (AMPK) α2-subunit and upregulates phosphorylated AMPK and nuclear factor erythroid 2-related factor 2 (Nrf2). Additionally, Rhodiola sacra increased heme oxygenase-1 (HO-1) expression and activity and reduced malondialdehyde (MDA) content in the hippocampal CA1 region. These findings demonstrate that Rhodiola sacra prevents oxidant stress and protects neurons through activating the AMPK/Nrf2 pathway.