Fatty acid composition and lipid profiles as chemotaxonomic markers of phytopathogenic fungi Puccinia malvacearum and P. glechomatis.

Researchers examined the fatty acid composition of the phytopathogenic fungi Puccinia malvacearum and P. glechomatis to determine their chemotaxonomic markers. Both species synthesized unusual fatty acids like 9,10-epoxy-octadecanoic acid and hydroxy fatty acids. Ultra-high performance liquid chromatography mass spectrometry revealed the complexity of molecular lipid species of these fungi. The lipid composition of P. malvacearum and P. glechomatis can be used in chemotaxonomic studies due to their diversity of neutral and polar lipids and fatty acids.

Wołczańska A et al (2021).

Fungal Biol.

DOI:

10.1016/j.funbio.2021.05.008

PubMed:

34649673

Withania somnifera (L.) Dunal (Ashwagandha): A comprehensive review on ethnopharmacology, pharmacotherapeutics, biomedicinal and toxicological aspects.

Paul S et al (2021).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2021.112175

PubMed:

34649336

Sambucus nigra: A traditional medicine effective in reducing inflammation in mice.

Santin JR et al (2022).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2021.114736

PubMed:

34648899

Target-directed evolution of novel modulators of the dopamine transporter in Lobelia cardinalis hairy root cultures.

Researchers identified lobinaline N-oxide, a water-soluble derivative of lobinaline, an atypical dopamine transporter (DAT) inhibitor lead from Lobelia cardinalis, through "target-directed evolution" of mutant L. cardinalis cell population expressing human DAT. Lobinaline N-oxide showed promising therapeutic potential to treat Substance Use Disorder (SUD) as it prolonged dopamine peak amplitudes in the ventral striatum and produced complex changes in post-peak dopamine clearance. Target-directed evolution of plant cells has been proved useful for lead optimization in drug development.

Rogers DT et al (2021).

J Biotechnol.

DOI:

10.1016/j.jbiotec.2021.10.001

PubMed:

34648893

A chromosome-scale Gastrodia elata genome and large-scale comparative genomic analysis indicate convergent evolution by gene loss in mycoheterotrophic and parasitic plants.

Xu Y et al (2021).

Plant J.

DOI:

10.1111/tpj.15528

PubMed:

34647389

Pharmacologic Activities of Plant-Derived Natural Products on Respiratory Diseases and Inflammations.

Timalsina D, Pokhrel KP and Bhusal D (2021).

Biomed Res Int.

DOI:

10.1155/2021/1636816

PubMed:

34646882

Evolutionary patterns of nucleotide substitution rates in plastid genomes of Quercus.

Li X et al (2021).

Ecol Evol.

DOI:

10.1002/ece3.8063

PubMed:

34646478

Functional Characterization of a New Bifunctional Terpene Synthase LpNES1 from a Medicinal Plant Laggera pter odonta.

Shi ZK et al (2021).

J Oleo Sci.

DOI:

10.5650/jos.ess21172

PubMed:

34645748