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Acteoside isolated from Colebrookea oppositifolia attenuates I/R brain injury in Wistar rats via modulation of HIF-1α, NF-κB, and VEGF pathways.

Acteoside, isolated from C. oppositifolia, was studied for its anti-stroke activity in Wistar rats. Rats were pretreated with acteoside at different doses before being subjected to ischemia-reperfusion brain injury. Neurological, motor-cognitive functions were evaluated along with morphological, biochemical, histopathological, and gene expression studies. Results showed that acteoside had a protective effect against I/R induced brain injury, making it a potential therapeutic agent for stroke treatment.

Viswanatha GL et al (2021).
Inflammopharmacology.
PubMed:
34365555