Molecular docking of antidiabetic molecules of libas (Spondias pinnata) fruit and prediction of their pharmacokinetic properties.

Researchers identified catechin in fruit as a potential antidiabetic compound through molecular docking. Catechin shows promise for drug development and could offer a more cost-effective solution for managing diabetes.

Diacos JEK et al (2024).

In Silico Pharmacol.

DOI:

10.1007/s40203-024-00230-3

PubMed:

38882504

The influence of storage conditions on the quality of Schisandra chinensis fruits: A integrated investigation of constituent and antioxidant activity.

Sheng Y et al (2024).

Heliyon.

DOI:

10.1016/j.heliyon.2024.e32194

PubMed:

38882346

Formulation of Phytosomes Containing Rubia cordifolia Extract for Neuropathic Pain: In Vitro and In Vivo Evaluation.

Researchers developed a phytosome delivery system for a plant extract with strong antioxidant properties. Formulation improved bioavailability of key compound, leading to increased neuroprotective effects and pain relief potential in nerve damage. Encapsulation may enhance treatment for neuropathic pain.

Kumar N et al (2024).

ACS Omega.

DOI:

10.1021/acsomega.4c03774

PubMed:

38882167

Natural Prenylflavones from the Stem Bark of Artocarpus altilis: Promising Anticancer Agents for Oral Squamous Cell Carcinoma Targeting the Akt/mTOR/STAT-3 Signaling Pathway.

Extracted compounds from Parkinson Fosberg bark showed promising cytotoxic effects on oral cancer cells by modulating protein expression and signaling pathways. Potential avenue for effective oral cancer management.

Aswathy M et al (2024).

ACS Omega.

DOI:

10.1021/acsomega.3c08376

PubMed:

38882137

Benzoylaconine Protects Skeletal Muscle Against Ischemia-Reperfusion Injury Through Activation of IF1-Dependent AMPK/Nrf2 Axis.

Researchers identified Benzoylaconine (BAC) as a key compound in (Fuzi) used to treat pain and muscle ailments. BAC shows promise for pharmacological applications.

Cui Y et al (2024).

Drug Des Devel Ther.

DOI:

10.2147/DDDT.S456699

PubMed:

38882050

Anemoside B4 attenuates abdominal aortic aneurysm by limiting smooth muscle cell transdifferentiation and its mediated inflammation.

Chu S et al (2024).

Front Immunol.

DOI:

10.3389/fimmu.2024.1412022

PubMed:

38881898

Cynanchum paniculatum (Bunge) Kitag. ex H.Hara inhibits pancreatic cancer progression by inducing caspase-dependent apoptosis and suppressing TGF-β-mediated epithelial-mesenchymal transition.

Study explores potential anti-cancer effects of (Bunge) Kitag. ex H.Hara in pancreatic cancer. CPAE inhibits proliferation, induces apoptosis, and suppresses metastasis. Promising herbal medicine for pancreatic cancer treatment.

Cheng CS et al (2024).

Front Pharmacol.

DOI:

10.3389/fphar.2024.1284371

PubMed:

38881872

Screening and analysis of the targeted compounds in Choerospondias axillaris extract by receptor chromatographic column with immobilized angiotensin II type 1 receptor.

Researchers developed a chromatographic method using an immobilized ATR to identify bioactive compounds in Tibetan medicine. Naringenin, pinocembrin, and chrysin were found to specifically bind to ATR, showing potential for drug development.

Ji X et al (2024).

Biomed Chromatogr.

DOI:

10.1002/bmc.5931

PubMed:

38881185