Polyphenols and Pharmacological Screening of a Monarda fistulosa L. dry Extract Based on a Hydrodistilled Residue By-Product.

Shanaida M et al (2021).

Front Pharmacol.

DOI:

10.3389/fphar.2021.563436

PubMed:

33995001

Accelerated delivery of dsRNA in lepidopteran midgut cells by a Galanthus nivalis lectin (GNA)-dsRNA-binding domain fusion protein.

Martinez Z et al (2021).

Pestic Biochem Physiol.

DOI:

10.1016/j.pestbp.2021.104853

PubMed:

33993971

Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus.

Abdellatef AA et al (2021).

J Nat Med.

DOI:

10.1007/s11418-021-01526-w

PubMed:

33988779

De novo transcriptome analysis and comparative expression profiling of genes associated with the taste-modifying protein neoculin in Curculigo latifolia and Curculigo capitulata fruits.

Okubo S et al (2021).

BMC Genomics.

DOI:

10.1186/s12864-021-07674-3

PubMed:

33985426

Natural plant products as potential inhibitors of RNA dependent RNA polymerase of Severe Acute Respiratory Syndrome Coronavirus-2.

Researchers investigated the interaction between phytochemicals from Indian medicinal plants and the RNA-dependent RNA polymerase (RdRP) of SARS-CoV-2. Using molecular docking and dynamics simulations, they identified four top phytochemicals, including cordifolide A and sitoindoside IX, which showed strong binding to RdRP and may serve as potential inhibitors. The study suggests that drug repurposing efforts can target RdRP inhibition and that natural compounds may hold promise as a treatment for COVID-19.

Koulgi S et al (2021).

PLoS One.

DOI:

10.1371/journal.pone.0251801

PubMed:

33984041

Bletilla striata Polysaccharide Promotes Diabetic Wound Healing Through Inhibition of the NLRP3 Inflammasome.

Zhao Y et al (2021).

Front Pharmacol.

DOI:

10.3389/fphar.2021.659215

PubMed:

33981238

In vitro biological activity of Salvia fruticosa Mill. infusion against amyloid β-peptide-induced toxicity and inhibition of GSK-3β, CK-1δ, and BACE-1 enzymes relevant to Alzheimer's disease.

Turkish sage, a species traditionally used to improve cognition, has anticholinergic effects and is a potential natural treatment for Alzheimer's disease. This study aimed to understand the mechanism behind its neuroprotective effects and investigate the inhibitory effects of its major compound, rosmarinic acid, on enzymes related to Alzheimer's disease. Results showed that the infusion significantly decreased amyloid beta-induced cytotoxicity and exhibited promising inhibitory activity against key enzymes. The study provides proof of the infusion's potential as a natural treatment for Alzheimer's disease.

Gürbüz P et al (2021).

Saudi Pharm J.

DOI:

10.1016/j.jsps.2021.01.007

PubMed:

33981172

Toxicological and anti-tumor effects of a linden extract (Tilia platyphyllos Scop.) in a HPV16-transgenic mouse model.

Ferreira T et al (2021).

Food Funct.

DOI:

10.1039/d1fo00225b

PubMed:

33978005