Phenolic Compounds from Carissa spinarum Are Characterized by Their Antioxidant, Anti-Inflammatory and Hepatoprotective Activities.
- Liu Y et al (2021).
- Antioxidants (Basel).
- PubMed:
- 33922451
The anti-convulsant effect of -hexane extract of fruit of L. was studied in a PTZ-induced animal model of epilepsy. Rats were treated with the extract or control, scored for convulsive behavior and seizures, and their brains analyzed. The extract significantly reduced seizures and increased survival rates. It also downregulated neuro-inflammation and expression of cytokine TNF-α and transcription factor NF-κB, and had various chemical constituents. The findings suggest potential for L. as an anti-convulsant agent.