Neuroprotective schinortriterpenoids from Schisandra neglecta collected in Medog County, Tibet, China.
- Wang B et al (2021).
- Bioorg Chem.
- PubMed:
- 33714022
This study investigated the effect of the antioxidant Kaempferol (KMP) on a rat model of Alzheimer's disease (AD) induced by the injection of STZ. The researchers found that KMP improved spatial memory in both male and female rats, as well as increasing levels of certain antioxidants in the hippocampus. The study suggests that KMP may be beneficial in treating cognitive impairments associated with AD, and that these benefits are not influenced by gender.
Star fruit toxicity can cause both kidney and neurological problems, especially in individuals with prior renal impairment. A review of ten case series and 28 case reports found that acute oxalate nephropathy with tubulointerstitial nephritis or tubular necrosis was common. Neurotoxicity manifestations ranged from hiccups to status epilepticus. The main substances causing nephrotoxicity and neurotoxicity were oxalate and caramboxin, which inhibits GABA binding and activates glutamatergic receptors. Early detection and renal replacement therapy can improve outcomes. Animal studies shed light on the underlying mechanisms of toxicity.