All Studies

Analyzing the Carotenoid Composition of Melilot (Melilotus officinalis (L.) Pall.) Extracts and the Effects of Isolated (All-E)-lutein-5,6-epoxide on Primary Sensory Neurons and Macrophages.

Scientists have investigated the carotenoid content of Meliloti herba, a medicinal plant with anti-inflammatory effects. Using high performance liquid chromatography (HPLC) and column liquid chromatography (CLC), they isolated and identified the main carotenoid as (all-)-lutein 5,6-epoxide and tested its effects on primary sensory neurons and macrophages involved in inflammation. Results showed that lutein 5,6-epoxide reduced the activation of primary sensory neurons and decreased the release of IL-1β from macrophages. This suggests that lutein 5,6-epoxide could be used as an analgesic and anti-inflammatory treatment.

ImmunologyNeuroscience Melilotus officinalis
Horváth G et al (2021).
Molecules.
DOI:
10.3390/molecules26020503
PubMed:
33477841

Myrtus communis improves cognitive impairment in renovascular hypertensive rats.

A study investigated the effects of Myrtus communis extract on cognitive function in rats with renovascular hypertension (RVH). The rats were divided into 4 groups and underwent tests for object recognition and spatial memory. Blood brain barrier integrity was also examined along with various biochemical parameters in the hippocampal tissue. The RVH group showed decreased cognitive function and impaired BBB permeability. The Myrtus communis extract treatment group showed improvement in cognitive function and restoration of biochemical parameters. The study suggests that Myrtus communis extract may improve cognitive function in hypertension through its various activities.

Neuroscience Myrtus communis
Cevikelli-Yakut ZA et al (2020).
J Physiol Pharmacol.
DOI:
10.26402/jpp.2020.5.07
PubMed:
33475094
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