All Studies

Application of HPLC-DAD for In Vitro Investigation of Acetylcholinesterase Inhibition Activity of Selected Isoquinoline Alkaloids from Sanguinaria canadensis Extracts.

This study explored the potential of certain plant extracts to inhibit acetylcholinesterase, an enzyme linked to neurodegenerative disorders. The extracts were obtained from plants collected before, during and after flowering, and were analyzed using a high performance liquid chromatography method. The results showed that most alkaloids in the extracts exhibited very high acetylcholinesterase activity inhibition, with IC values ranging from 0.36 to 89.14 µg/mL. The study suggests that these plant extracts have potential for further investigation as a treatment for neurodegenerative disorders such as Alzheimer's disease.

Tuzimski T and Petruczynik A (2021).
Molecules.
PubMed:
33466254

Layer-by-layer assembly strategy for fabrication of polydopamine-polyethyleneimine hybrid modified fibers and their application to solid-phase microextraction of bioactive molecules from medicinal plant samples followed by surface plasmon resonance biosensor validation.

A new method called solid-phase microextraction has been developed to identify bioactive compounds in medicinal plants. The method avoids the use of large amounts of organic solvents and is environmentally friendly. Polyvinylidene fluoride fibers coated with polydopamine and polyethyleneimine were used as a solid part of the extractors. The fibers were placed in a sample solution of medicinal plants, stirred and then removed. The method was optimized by varying the temperature, ion strength, and pH. Nine bioactive components were obtained from Plantago depressa extract. The method had high precision, accuracy, and stability, and was confirmed through surface plasmon resonance biosensor. This new method is a powerful tool for locating bioactive compounds in medicinal plants.

Tao Y, Chen L and Jiang E (2021).
Anal Chim Acta.
PubMed:
33461711