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Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence.

The study examined how extracts from the plant CH can protect human neuroblastoma cells from the effects of high glucose. The extracts were tested for their chemical contents and antioxidant activity. Results showed that the extracts prevented neuronal senescence by inhibiting the production of reactive oxygen species and inducing cell cycle progression. This was achieved through the downregulation of certain proteins and the up-regulation of SIRT1, which improved neuronal cell functions. The study suggests that CH extracts have potential therapeutic benefits for neurodegenerative diseases and could be used to relieve various health ailments as a natural remedy.

Pattarachotanant N and Tencomnao T (2020).
Pharmaceuticals (Basel).
PubMed:
33007805