Phytochemistry, Traditional Use and Pharmacological Activity of Picrasma quassioides: A Critical Reviews.
- Mohd Jamil MDH et al (2020).
- Nutrients.
- DOI:
- 10.3390/nu12092584
- PubMed:
- 32858812
Researchers aimed to identify potential drug candidates for COVID-19 treatment by screening 100 phytocompounds for their binding affinity to the N-terminal domain of nucleocapsid phosphoprotein of SARS-CoV-2. Molecular docking and simulation techniques were used to study the interaction stability of the best three protein-ligand complexes. The phytocompounds which showed good binding affinity and met drug likeness properties and non-toxicity were identified as potential therapy for COVID-19. Alizarin, aloe-emodin, and anthrarufin were identified as the most promising phytocompounds and can be further tested for use as a potential drug to cure SARS-CoV-2 infection.