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Effect of Andrographis paniculata and Phyllanthus amarus leaf extracts on selected biochemical indices in Drosophila melanogaster model of neurotoxicity.

Researchers investigated the effect of alkaloid extracts from and leaves on aluminum-induced toxicity in fruit flies. The flies were exposed to aluminum and the extracts, then assessed for learning, memory, and movement. The results suggest that the alkaloids improved behavioral and biochemical impairments caused by aluminum toxicity. Amaryllidaceae alkaloids, caffeine, and carpaine were found in the extracts. These findings indicate that alkaloid extracts from these leaves could potentially be used to manage neurodegenerative diseases.

Adedayo BC et al (2022).
Drug Chem Toxicol.
PubMed:
31899970