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Effects of Picrasma quassioides and its active constituents on Alzheimer's disease in vitro and in vivo.

Researchers have discovered potential neuroprotective properties in Picrasma quassioides, a Chinese traditional medicine used for treating inflammation, fever, microbial infection, and dysentery. The extract from the stems was found to improve memory and cognitive abilities in Alzheimer's disease (AD) mice and suppress neuroinflammation and reduce Aβ deposition. A systematic phytochemistry study led to the identification of six β-carboline alkaloids, seven canthin-6-one alkaloids, and five quassinoids, of which four β-carbolines and six canthin-6-ones exhibited potential neuroprotective activities in vitro. Compounds 2 and 3 exhibited high affinity for both DYPKIA and BuChE through molecular docking experiments. These findings suggest the potential of Picrasma quassioides in developing AD treatments.

Guo E et al (2019).
Bioorg Chem.
PubMed:
31520892