Rosanortriterpenes A-B, two new nortriterpenes from the fruits of Rosa laevigata var. leiocapus.
- Tian YN et al (2021).
- Nat Prod Res.
- PubMed:
- 31328555
The compound aminochrome can cause brain damage and a Parkinson's-like condition. The enzyme GSTM2 in brain cells can protect against aminochrome, but sometimes the protection is not strong enough. Some medicines made from plants may also protect against aminochrome damage.
Researchers investigated different extracts of a plant for their antioxidant and enzyme inhibitory effects. All extracts showed antiradical effects, with methanol and aqueous extracts being the best sources of antioxidants. Methanol and ethyl acetate extracts were potent against enzymes that are targets for Alzheimer's disease. The extracts were also studied in an in vitro neurotoxicity paradigm, which showed that the water extract of one of the subspecies of the plant had a neuroprotective effect. The water extract was able to prevent an increase in certain biomarkers associated with brain damage and to restore the activity of certain proteins that are important for neuron function. These findings suggest that extracts from this plant may have a therapeutic role in the treatment of neurodegenerative diseases.