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Korean Thistle (Cirsium japonicum var. maackii (Maxim.) Matsum.): A Potential Dietary Supplement against Diabetes and Alzheimer's Disease.

Researchers investigated the activity of different parts of Korean thistle for their potential to inhibit diabetes and Alzheimer's disease. Ethyl acetate and dichloromethane fractions of the leaf extract showed α-glucosidase and BACE1 inhibitory activity, respectively. Luteolin, an isolated compound, also exhibited non-competitive inhibition against both α-glucosidase and BACE1. Docking studies showed that luteolin formed a strong hydrogen bond with the peripheral binding amino acid residues and hydrophobic interactions with the enzymes. Korean thistle may be a dietary supplement against these diseases, especially the leaves, due to the preponderance of active luteolin. This promising candidate warrants further in vitro and in vivo studies.

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Progress in Somatic Embryogenesis of Japanese Pines.

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