Sulfonic Acid-Containing Flavonoids from the Roots of Phyllanthus acidus.
- Duong TH et al (2018).
- J Nat Prod.
- PubMed:
- 30207470
Researchers studied the effect of Dracocephalum heterophyllum Benth flavonoid (DHBF), a traditional medicine used to treat various disorders, on cardiomyocyte hypertrophy in cultured cells. Neonatal rat cardiomyocytes were cultured and hypertrophy was induced using angiotensin II (Ang II). Ang II treatment reduced cell viability and increased the expression of cardiac hypertrophy genes. DHBF treatment reversed these effects in a concentration-dependent manner and may be related to the release of nitric oxide and regulation of intracellular calcium concentration. This study demonstrates the potential of DHBF in treating cardiomyocyte hypertrophy.