GeoBotanical: All Studies

17849.

Estrogen Receptor β Mediated Neuroprotective Efficacy of Cicer microphyllum Seed Extract in Global Hypoxia.

Researchers investigated the potential of Cicer microphyllum seed extract (CSE) to reduce neurodegeneration and improve memory in rats exposed to chronic hypoxia (low oxygen levels). CSE reduced neurodegeneration and dendritic atrophy in CA1 neurons and improved memory in hypoxic rats. This was attributed to antioxidant activity, activation of estrogen receptor beta (ERβ), and phosphorylation of extracellular signal regulated kinase (ERK1/2), resulting in increased expression of PSD-95. CSE also promoted dendritic arborization and independent of brain derived neurotrophic factor (BDNF) mediated signalling mechanisms. The findings suggest the neuroprotective potential of CSE in hypoxia and provide evidence for involvement of estrogen receptor and pCREB-mediated nootropic effect of the extract. Toxicological studies show that CSE is safe for consumption.

Endocrinology Neuroscience Cicer microphyllum

Sharma D et al (2017).; Neurochem Res.
DOI:: 10.1007/s11064-017-2395-5
PubMed:: 28861754

17850.

Aralia elata inhibits neurodegeneration by downregulating O-GlcNAcylation of NF-κB in diabetic mice.

Diabetes Immunology Neuroscience Aralia elata

Kim SJ et al (2017).; Int J Ophthalmol.
DOI:: 10.18240/ijo.2017.08.03
PubMed:: 28861343

17851.

Effects of Ecballium elaterium on brain in a rat model of sepsis-associated encephalopathy.

Researchers studied the effects of Ecballium elaterium (EE) on sepsis-associated encephalopathy (SAE), a major clinical challenge in intensive care units. They induced SAE in 30 rats with cecal ligation and puncture (CLP), then divided them into three groups: control, sepsis, and treatment. The treatment group received 2.5 mg/kg of EE. After 24 hours, the brain tissue was analyzed for levels of cytokines, antioxidants, and inflammation. The treatment group showed a statistically significant reduction in brain tissue levels of proinflammatory cytokines and a decrease in histopathologic changes associated with SAE. EE contains components that may help protect against SAE by reducing inflammation.

Neuroscience Ecballium elaterium

Arslan D et al (2017).; Libyan J Med.
DOI:: 10.1080/19932820.2017.1369834
PubMed:: 28859554

17852.

Pterocarpus santalinus L. Regulated Ultraviolet B Irradiation-induced Procollagen Reduction and Matrix Metalloproteinases Expression Through Activation of TGF-β/Smad and Inhibition of the MAPK/AP-1 Pathway in Normal Human Dermal Fibroblasts.

Immunology Pterocarpus santalinus

Gao W et al (2018).; Photochem Photobiol.
DOI:: 10.1111/php.12835
PubMed:: 28858391

17853.

Antioxidant and anti-inflammatory activities of Geranium robertianum L. decoctions.

Immunology Geranium robertianum

Catarino MD et al (2017).; Food Funct.
DOI:: 10.1039/c7fo00881c
PubMed:: 28858365

17854.

Complete Chloroplast Genome Sequence of Decaisnea insignis: Genome Organization, Genomic Resources and Comparative Analysis.

Genetics Decaisnea insignis

Li B et al (2017).; Sci Rep.
DOI:: 10.1038/s41598-017-10409-8
PubMed:: 28855603

17855.

Condensation patterns of prophase/prometaphase chromosome are correlated with H4K5 histone acetylation and genomic DNA contents in plants.

Genetics Callisia repens

Feitoza L, Costa L and Guerra M (2017).; PLoS One.
DOI:: 10.1371/journal.pone.0183341
PubMed:: 28854212

17856.

ANTIMICROBIAL ACTIVITY OF GYMNOSPERMA GLUTINOSUM (SPRENG.) LESS. (ASTERACEAE) METHANOL EXTRACTS AGAINST HELICOBACTER PYLORI.

Antimicrobial Gymnosperma glutinosum

Gomez-Flores R et al (2016).; Afr J Tradit Complement Altern Med.
DOI:: 10.21010/ajtcam.v13i4.9
PubMed:: 28852720