All Studies

Ameliorative potential of Colebrookea oppositifolia methanolic root extract against experimental models of epilepsy: Possible role of GABA mediated mechanism.

Colebrookea oppositifolia Smith plant is used by various folk medicine groups in sub-Himalayan regions of India to treat epilepsy.

Viswanatha GL, Venkataranganna MV and Prasad NBL (2017).
Biomed Pharmacother.
PubMed:
28391167

Di-(2-ethylhexyl) Phthalate-Induced Hippocampus-Derived Neural Stem Cells Proliferation.

A study investigated the effects of di-(2-ethylhexyl) phthalate (DEHP) and a hydroethanolic extract on the proliferation of neural stem cells (NSCs) derived from rat hippocampus, aiming to find phytochemical candidates for treating neurological diseases. The cells were treated with different concentrations of DEHP and the extract, and growth rates and gene expressions were measured. The highest growth rate was observed in the groups treated with 400 µM DEHP and 800 µg/ml extract. DEHP significantly increased gene expression in NSCs compared to the control group. The phytochemicals present in the extract, which included 2-ethyl-1-hexanamine and n-heptacosane, were also identified using GC/MS. These findings suggest the potential application of C. vulgure phytochemicals in promoting endogenous adult NSCs proliferation for the prevention and treatment of neurological diseases.

Abdanipour A et al (2017).
Cell J.
PubMed:
28367427