Neuroprotective Activity of Cerebrosides from Typhonium giganteum by Regulating Caspase-3 and Bax/Bcl-2 Signaling Pathways in PC12 Cells.
- Jin Y et al (2017).
- J Nat Prod.
- PubMed:
- 28394604
Colebrookea oppositifolia Smith plant is used by various folk medicine groups in sub-Himalayan regions of India to treat epilepsy.
A study investigated the effects of di-(2-ethylhexyl) phthalate (DEHP) and a hydroethanolic extract on the proliferation of neural stem cells (NSCs) derived from rat hippocampus, aiming to find phytochemical candidates for treating neurological diseases. The cells were treated with different concentrations of DEHP and the extract, and growth rates and gene expressions were measured. The highest growth rate was observed in the groups treated with 400 µM DEHP and 800 µg/ml extract. DEHP significantly increased gene expression in NSCs compared to the control group. The phytochemicals present in the extract, which included 2-ethyl-1-hexanamine and n-heptacosane, were also identified using GC/MS. These findings suggest the potential application of C. vulgure phytochemicals in promoting endogenous adult NSCs proliferation for the prevention and treatment of neurological diseases.