Triterpene saponins from the roots of Acacia albida Del. (Mimosaceae).
- Tchoukoua A et al (2017).
- Phytochemistry.
- PubMed:
- 28043655
Researchers have discovered potential new compounds that could serve as anti-neuroinflammatory agents by inhibiting the production of nitric oxide in activated microglia cells. The compounds were isolated from the roots of the Pteridaceae plant and include three new -kaurane diterpenoids, along with nine other known compounds. The new compounds were shown to reduce levels of pro-inflammatory mediators, such as PGE₂, TNF-α, IL-1β, and IL-6. These findings highlight the potential of -kaurane diterpenes from Pteridaceae as new agents in the fight against neurodegenerative diseases, including Alzheimer's disease.