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This study compared the effects of Passiflora incarnata and midazolam for controlling anxiety in patients undergoing surgery to remove their mandibular third molar. Anxiety is a common issue for dental patients during both minor and major procedures. Passiflora incarnata and midazolam were compared for their ability to reduce anxiety. The results demonstrated that Passiflora incarnata was equally effective at reducing anxiety as midazolam, but with fewer negative side effects. This suggests that natural remedies like Passiflora incarnata may be a feasible alternative to synthetic drugs for dental patients experiencing anxiety.