Antinociceptive Activity of an Ethanol Extract of Justicia spicigera.
- Zapata-Morales JR et al (2016).
- Drug Dev Res.
- DOI:
- 10.1002/ddr.21307
- PubMed:
- 27149602
Researchers analyzed essential oils from two populations of Ballota macedonica and Ballota nigra ssp. foetida. They identified a total of 85 components, with B. macedonica from the Former Yugoslav Republic of Macedonia having the highest number of components. The most abundant components were carotol, germacrene D, and (E)-caryophyllene in B. macedonica oils, while (E)-phytol, germacrene D, and (E)-caryophyllene dominated in B. nigra ssp. foetida oil. The researchers used statistical analysis to compare and discuss the relationships among Ballota species based on their volatile profiles. This study presents the first report of the chemical composition of B. macedonica essential oils.
Artemisia indica (Mugwort) has been traditionally used for medicinal purposes. Researchers isolated three compounds from the herb - carnosol, ursolic acid, and oleanolic acid. These compounds were tested on GABA-A receptors in Xenopus oocytes and in mouse models of acute toxicity, convulsions, depression, and anxiety. The compounds were found to be beneficial for the central nervous system and were demonstrated to have anticonvulsant, antidepressant, and anxiolytic effects. The effects were linked to the benzodiazepine binding site of GABA-A receptors. The study provides evidence of the positive effects of nonvolatile components of Artemisia indica on the central nervous system.