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The non-competitive blockade of GABAA receptors by an aqueous extract of water hemlock (Cicuta douglasii) tubers.

Water hemlocks are extremely toxic plants due to the presence of cicutoxin. This study investigated the effect of an aqueous extract of water hemlock on GABAA receptors in WSS-1 cells. Noncompetitive blockade of the receptors was observed, indicating the potential mechanisms behind the plant's toxicity. Additionally, researchers found that midazolam could modulate the blockade, which could have implications for treatment options in cases of water hemlock poisoning.

Green BT et al (2015).
Toxicon.
PubMed:
26415905