All Studies

Inhibitory effect of reinioside C on vascular smooth muscle cells proliferation induced by angiotensin II via inhibiting NADPH oxidase-ROS-ENK1/2-NF-kappaB-AP-1 pathway.

The study investigated the effect of reinioside C on the proliferation of vascular smooth muscle cells (VSMCs) induced by angiotensin II (Ang II), which plays a role in arteriosclerosis and restenosis. Treatment with reinioside C inhibited the proliferative effect of Ang II in a concentration-dependent manner. The possible mechanism was found to involve attenuation of Ang II-induced NADPH oxidase mRNA expression, generation of ROS, ERK1/2 phosphorylation, activation of NF-kappaB, and mRNA expression of AP-1 and c-myc in VSMCs. The study suggests that reinioside C inhibits the proliferation of VSMCs induced by Ang II by inhibiting the NADPH oxidase-ROS-ERK1/2-NF-kappaB-AP-1 pathway.

Hong D et al (2014).
Pharmazie.
PubMed:
25272943

Evidence for reciprocal origins in Polypodium hesperium (Polypodiaceae): a fern model system for investigating how multiple origins shape allopolyploid genomes.

Sigel EM, Windham MD and Pryer KM (2014).
Am J Bot.
PubMed:
25253708

A novel diterpene skeleton: identification of a highly aromatic, cytotoxic and antioxidant 5-methyl-10-demethyl-abietane-type diterpene from Premna serratifolia.

Habtemariam S and Varghese GK (2015).
Phytother Res.
PubMed:
25250850