Triterpenoids from the fruits and leaves of the blackberry (Rubus allegheniensis) and their inhibitory activities on foam cell formation in human monocyte-derived macrophage.
- Ono M et al (2014).
- Nat Prod Res.
- PubMed:
- 25033392
Researchers have isolated four new alkaloids and ten known analogues from the whole plant of Lycopodiastrum casuarinoides. The new compounds' structures were determined using a variety of spectroscopic and chemical methods. Notably, compound 4 was a lycopodium alkaloidal glycoside never before reported. Four of the isolated compounds showed significant inhibitory activity against acetylcholinesterase, which is linked to Alzheimer's disease. The structure-activity relationships were discussed, potentially informing future treatments.