A new sesquiterpene lactone from Elephantopus tomentosus.
- Wang B et al (2012).
- J Asian Nat Prod Res.
- PubMed:
- 22582752
Researchers examined the pain-relieving effects of Agrimonia pilosa Ledeb extract in mice. They found that oral administration of the extract (200 mg/kg) reduced pain as measured by various tests. The extract also reduced the nociceptive response to a substance that causes pain when injected into the spinal cord. The antinociceptive effect was blocked by a drug that blocks alpha-2 adrenergic receptors, but not by drugs that block opioid or serotonergic receptors. These findings suggest that Agrimonia pilosa Ledeb extract has pain-relieving properties, and that it may work by affecting alpha-2 adrenergic receptors.