All Studies

Identification of GABA A receptor modulators in Kadsura longipedunculata and assignment of absolute configurations by quantum-chemical ECD calculations.

Researchers have found that compounds within Kadsura longipedunculata, a plant from the Schisandraceae family, enhance the GABA-induced chloride current in Xenopuslaevis oocytes expressing GABA A receptors. Thirteen compounds were identified as having GABA A receptor activity and tested in preparative scale. All but one of the 13 compounds potentiated the GABA-induced chloride current. The phytochemical profiles of petroleum ether extracts of Kadsura japonica fruits and Schisandra chinensis fruits were compared with that of K. longipedunculata. These findings suggest that compounds from K. longipedunculata have potential as therapeutic agents for conditions related to GABA A receptors.

Zaugg J et al (2011).
Phytochemistry.
PubMed:
21889177

Antioxidant, hepatoprotective, and ameliorative effects of methanolic extract of leaves of Grewia mollis Juss. on carbon tetrachloride-treated albino rats.

Asuku O, Atawodi SE and Onyike E (2012).
J Med Food.
PubMed:
21877945