Anxiolytic-like effects of standardized extract of Justicia pectoralis (SEJP) in mice: Involvement of GABA/benzodiazepine in receptor.
An extract from Justicia pectoralis, a plant used for its anti-inflammatory and antimicrobial properties, was tested in mice for its anxiolytic effects. The extract was administered intragastrically at varying doses and compared to diazepam as a standard drug. Results showed that the extract had an anxiolytic-like effect similar to diazepam in the elevated plus maze test without causing sedative effects. This suggests that the extract could have potential as an alternative treatment for anxiety disorders. Flumazenil was used to evaluate the participation of benzodiazepinic receptors.
- Venâncio ET et al (2011).
- Phytother Res.
- DOI:
- 10.1002/ptr.3274
- PubMed:
- 20737656