Alpha-cyperone mitigates renal ischemic injury via modulation of HDAC-2 expression in diabetes: Insights from molecular dynamics simulations and experimental evaluation.

Alpha-cyperone from Cyperus rotundus protects kidneys of diabetic rats from injury by reducing oxidative stress, inflammation, and inhibiting HDAC-2 activity. Promising potential treatment for diabetic kidney damage.

Daude RB, Bhadane R and Shah JS (2024).

Eur J Pharmacol.

DOI:

10.1016/j.ejphar.2024.176643

PubMed:

38754539

A network pharmacology-based method to explore the therapeutic effect of honokiol on diabetes with comorbid depression in mice.

Honokiol from Magnolia officinalis may help treat diabetes with depression by activating RXR/VDR heterodimer. This could restore autophagy balance and improve neuroplasticity in the hippocampus.

Sun H et al (2024).

Eur J Pharmacol.

DOI:

10.1016/j.ejphar.2024.176642

PubMed:

38754538

Pollen-mediated gene flow from wild carrots (Daucus carota L. subsp. carota) affects the production of commercial carrot seeds (Daucus carota L. subsp. sativus) internationally and in New Zealand in the context of climate change: A systematic review.

Godwin A et al (2024).

Sci Total Environ.

DOI:

10.1016/j.scitotenv.2024.173269

PubMed:

38754518

Serum metabolomics analyses reveal biomarkers of osteoporosis and the mechanism of Quanduzhong capsules.

Yi B et al (2024).

J Pharm Biomed Anal.

DOI:

10.1016/j.jpba.2024.116198

PubMed:

38754154

Gene flow from Fraxinus cultivars into natural stands of Fraxinus pennsylvanica occurs range-wide, is regionally extensive, and is associated with a loss of allele richness.

Abhainn EA et al (2024).

PLoS One.

DOI:

10.1371/journal.pone.0294829

PubMed:

38753718

6-Gingerol ameliorates ulcerative colitis by inhibiting ferroptosis based on the integrative analysis of plasma metabolomics and network pharmacology.

Li W et al (2024).

Food Funct.

DOI:

10.1039/d4fo00952e

PubMed:

38753306

Evaluating the effects of various ethanolic medicinal plant extracts on metastatic breast cancer proliferation, invasion, and expression of a novel potential drug target; CD82 metastatic suppressor protein, and on in vivo angiogenesis using the ex ovo yolk sac membrane (YSM) assay.

Researchers screened plant extracts for anti-metastatic properties in breast cancer cells by targeting CD82 expression. Results show potential for multi-system treatment to inhibit metastasis and improve patient outcomes.

Loggenberg S, Twilley D and Lall N (2024).

J Cancer Res Clin Oncol.

DOI:

10.1007/s00432-024-05751-0

PubMed:

38753184

Silver sulphide nanoparticles (Ag(2)SNPs) synthesized using Phyllanthus emblica fruit extract for enhanced antibacterial and antioxidant properties.

Renuka R et al (2024).

Microsc Res Tech.

DOI:

10.1002/jemt.24612

PubMed:

38752356