Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity.
- Tognolini M et al (2006).
- Life Sci.
- PubMed:
- 16274702
Researchers studied the protective effects of Polygala paniculata extract on adult mice exposed to methylmercury (MeHg). MeHg exposure reduced glutathione peroxidase and increased glutathione reductase activity, as well as increased thiobarbituric acid reactive substances in the brain. Polygala extract prevented these effects, except for glutathione reductase activity in the cerebral cortex. MeHg-exposed animals had poor motor performance, which was improved by Polygala extract co-administration. This study demonstrated the in-vivo protective effects of Polygala extract against MeHg-induced neurotoxicity and encourages further research on its use for neurological conditions related to excitotoxicity and oxidative stress.