Piperlongumine (PLN) shows potential as an anticancer agent. It increases ROS levels and DNA damage, inhibits antioxidant enzymes, and induces genotoxicity. It inhibits DDR proteins, leading to cell death in non-tumor cells and reduced cell viability in breast cancer cells.
Researchers have been studying the development of vaccines, repurposing approved drugs, and natural compounds for COVID-19. Gender differences in disease severity suggest that sex hormones could be involved. Androgens upregulate ACE2, a key receptor for the virus, while androgen antagonists can lower ACE2 levels, potentially aiding in COVID-19 management.
This study investigated the use of baicalein, a flavonoid with multiple therapeutic properties, for the treatment of diabetes. Aquasomes were used to enhance its solubility, potentially facilitating its delivery as a drug. This research is important as it explores a promising approach to effectively treat metabolic abnormalities induced by diabetes.
Daphne gnidium plant was investigated for its ability to lower blood pressure. Relevant for finding potential natural remedies to combat hypertension.
In this study, the researchers investigated the biological functions of Verbascum thapsus methanol extract. They used chromatography and spectrometry to analyze its composition, and tested its antioxidant capacity and cytotoxicity on different cell lines. The extract showed low antioxidant activity but inhibited acetylcholinesterase enzyme.
Researchers analyzed 108 universal stress protein genes in the potato genome, finding they play a role in plant-pathogen response, hormone signaling, and metabolite biosynthesis, highlighting their importance for potato's response to adversity stress. This study lays the groundwork for further research on these genes.
The study found that an apolar supercritical CO extract of St. John's wort showed better effects against Alzheimer's disease (AD) compared to other extracts. It improved food intake, body weight, and reduced soluble and insoluble Aβ, suggesting it could be a recommended treatment for mild cognitive impairment or early AD.