All Studies

Isolation of an α-glucosidase Inhibitor from Houttuynia cordata Thunb. and Its In vitro and In vivo Hypoglycemic Bioactivity.

Researchers isolated neochlorogenic acid from Houttuynia cordata Thunb., showing potential as a natural α-glucosidase inhibitor to lower blood glucose levels. This study lays the groundwork for developing new hypoglycemic treatments.

Cao P et al (2024).
Plant Foods Hum Nutr.
PubMed:
39133356

Hippophae Rhamnoides-derived Phytomedicine Nano-System Modulates Bax/Fas Pathways to Reduce Proliferation in Triple-Negative Breast Cancer.

Innovative phyto-nanomedicine with sea buckthorn polyphenols and metformin inhibits triple-negative breast cancer cells and induces regulated cell death. Promising potential for effective and less genotoxic TNBC therapy.

Farheen J et al (2024).
Adv Healthc Mater.
PubMed:
39132863

Correction to: A mutation in the brassinosteroid biosynthesis gene CpDWF5 disrupts vegetative and reproductive development and the salt stress response in squash (Cucurbita pepo).

(2024).
Hortic Res.
PubMed:
39132642

Dialyl-sulfide with trans-chalcone prevent breast cancer prohibiting SULT1E1 malregulations and oxidant-stress induced HIF1a-MMPs induction.

Researchers found that in specific types of breast cancer, changes in SULT1E1 and HIF1α factors can impact estrogen levels and tissue damage. Testing drug combinations targeting SULT1E1 may offer protective benefits in breast cancer treatment.

Nazmeen A, Maiti S and Maiti S (2024).
Genes Cancer.
PubMed:
39132498

Development of semisynthetic saponin immunostimulants.

Extensive structure-activity-relationship studies on natural saponins reveal that replacing ester side chains with amide side chains could generate potent immunostimulants. This research led to the discovery of VSA-1 and VSA-2, which could offer new options for immunostimulatory adjuvants.

Bai D, Kim H and Wang P (2024).
Med Chem Res.
PubMed:
39132259