All Studies

Azadiradione up-regulates the expression of parvalbumin and BDNF via Ube3a.

The compound azadiradione found in Neem seeds has shown potential in improving synaptic function by increasing expression of Ube3a, parvalbumin, and BDNF. This suggests a possible role in treating neuropsychiatric/neurodegenerative disorders.

Jana S et al (2023).
Gene.
PubMed:
38101713

Higenamine exerts antidepressant effect by improving the astrocytic gap junctions and inflammatory response.

Researchers investigated the effects of higenamine, found in Fuzi herb, on depression. Higenamine improved the dysfunction of gap junctions between astrocytes and reduced neuroinflammation. This suggests higenamine may be a potential treatment for neuropsychiatric disorders, including depression.

Yao J et al (2023).
J Affect Disord.
PubMed:
38101523

Metagenomic sequencing revealed the regulative effect of Danshen and Honghua herb pair on the gut microbiota in rats with myocardial ischemia injury.

DHHP, a Chinese herb pair, relieves myocardial ischemia in rats by regulating gut microbiota. It improves diversity and increases beneficial bacteria while reducing harmful bacteria, offering potential for MI treatment.

Du SB et al (2024).
FEMS Microbiol Lett.
PubMed:
38100390

Isolation and in silico investigation of cannflavins from Cannabis sativa leaves as potential anti-SARS-CoV-2 agents targeting the Papain-Like Protease.

This study identified three prenylflavonoids from leaves that show potential against SARS-CoV-2. The compounds have structural similarities to a ligand of the virus' Papain-Like Protease and successfully bind to its active pocket. Further research is needed to confirm their effectiveness and safety.

Wanas AS et al (2023).
Nat Prod Res.
PubMed:
38100380