Involvement of estrogen receptor activation in kaempferol-3-O-glucoside's protection against aging-related cognition impairment and microglial inflammation.

Kaempferol-3-O-glucoside (K-3-G), a flavonoid in Cuscuta Chinensis Lam., improved cognition and reduced inflammation in aging mice. It activated estrogen receptors (ERs) and inhibited microglial inflammation through ERs, suggesting it could be a therapeutic agent for cognitive decline.

Liu H et al (2023).

Exp Cell Res.

DOI:

10.1016/j.yexcr.2023.113849

PubMed:

37926343

Seventeen undescribed iridoid derivatives with anti-inflammatory effects from Hedyotis diffusa and their structure-activity relationships.

Qin LF et al (2023).

Phytochemistry.

DOI:

10.1016/j.phytochem.2023.113904

PubMed:

37926152

Macelignan prevents colorectal cancer metastasis by inhibiting M2 macrophage polarization.

Researchers investigated the effect of macelignan, a compound found in Myristica fragrans, on the polarization of tumor-associated macrophages in colorectal cancer metastasis. Understanding this interaction can potentially lead to new strategies for cancer treatment. (37 words)

Che N et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.155144

PubMed:

37925889

Comparative physiochemical and transcriptomic analysis reveals the influences of cross-pollination on ovary and fruit development in pummelo (Citrus maxima).

Cross-pollination with Guanximiyou pummelo improves the fruit shape (FS) quality of Shuijingmiyou pummelo. Physiochemical and transcriptomic differences were found between self-pollinated and cross-pollinated fruits. This study provides insight into the influence of cross-pollination on pummelo fruit development and quality improvement.

Wang S et al (2023).

Sci Rep.

DOI:

10.1038/s41598-023-46058-3

PubMed:

37925539

The anticancer potential of chemical constituents of Moringa oleifera targeting CDK-2 inhibition in estrogen receptor positive breast cancer using in-silico and in vitro approches.

Scientists investigated the potential of compounds in Moringa oleifera to inhibit CDK-2, a protein target in estrogen receptor-positive breast cancer. Ellagic acid, chlorogenic acid, and quercetin showed the most promise and further research is needed to validate these findings.

Sultan R et al (2023).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-04198-z

PubMed:

37925393

Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin.

Researchers studied the effectiveness of plumbagin in inhibiting cell growth, tumor metastasis, and inducing apoptosis in tongue squamous cell carcinoma. Findings may lead to new therapies for this type of cancer with a poor prognosis.

Xin Y et al (2023).

Aging (Albany NY).

DOI:

10.18632/aging.205175

PubMed:

37925175

Integrated analysis of miRNA, transcriptome, and degradome sequencing provides new insights into lipid metabolism in perilla seed.

Zou X et al (2023).

Gene.

DOI:

10.1016/j.gene.2023.147953

PubMed:

37925118

Genome-wide identification and expression analysis reveal the role of histone methyltransferase and demethylase genes in heat stress response in potato (Solanum tuberosum L.).

Mali S and Zinta G (2024).

Biochim Biophys Acta Gen Subj.

DOI:

10.1016/j.bbagen.2023.130507

PubMed:

37925032