All Studies

Mollugin suppresses proliferation and drives ferroptosis of colorectal cancer cells through inhibition of insulin-like growth factor 2 mRNA binding protein 3/glutathione peroxidase 4 axis.

Mollugin, a compound from Rubia cordifolia, induces ferroptosis in colorectal cancer (CRC) cells by reducing GSH and increasing ROS, Fe, and MDA levels. Inhibition of ferroptosis reverses the antitumor effects of mollugin. High expression of IGF2BP3 in CRC suggests poor prognosis. Mollugin may be a promising CRC therapy by targeting the IGF2BP3/GPX4 axis.

Wang W et al (2023).
Biomed Pharmacother.
PubMed:
37677963

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases.

Various bioactive metabolites found in herbs such as Rosmarinus officinalis and Punica granatum have shown impressive angiotensin converting enzyme (ACE) inhibitory activity. These natural ACE inhibitors could be a potential treatment for hypertension, respiratory distress syndrome, and chronic kidney diseases, but more clinical trials are needed.

Khaled A et al (2023).
Phytother Res.
PubMed:
37675925