All Studies

Polyphyllin VII induces autophagy-dependent ferroptosis in human gastric cancer through targeting T-lymphokine-activated killer cell-originated protein kinase.

Polyphyllin VII (PPVII), a compound found in Paris polyphylla, can inhibit gastric cancer (GC) by inducing autophagy-mediated ferroptosis. PPVII activates the ULK1 pathway, inhibits the activity of the protein TOPK, and stabilizes its inactive form, suggesting PPVII could be a potential treatment for GC.

Xiang Y et al (2023).
Phytother Res.
PubMed:
37632389

Cytotoxic Screening and Enhanced Anticancer Activity of Lippia alba and Clinopodium nepeta Essential Oils-Loaded Biocompatible Lipid Nanoparticles against Lung and Colon Cancer Cells.

This study evaluated the cytotoxic activity of plant and herbal essential oils (EOs) against lung and colon cancer cells. The most potent EOs were encapsulated into solid lipid nanoparticles (SLN) to enhance their anticancer activity. SLN/CnEO was found to be safe and significantly increased cancer cell death and inhibition of cell migration.

Rodenak-Kladniew B et al (2023).
Pharmaceutics.
PubMed:
37631258

An In Vitro Evaluation and Network Pharmacology Analysis of Prospective Anti-Prostate Cancer Activity from Perilla frutescens.

L. Britt. leaf extracts contain rosmarinic acid, which exhibits potent cytotoxic effects on prostate cancer cells and interacts with multiple targets and pathways involved in prostate cancer. These findings suggest a potential use of L. Britt. leaves or their metabolites in prostate cancer treatment and prevention.

Garcia PJB et al (2023).
Plants (Basel).
PubMed:
37631218