Clinical Trial

Antihypertensive efficacy and safety of Vaccinium arctostaphylos berry extract in overweight/obese hypertensive patients: A randomized, double-blind and placebo-controlled clinical trial.

This study investigated the effectiveness and safety of a particular extract from V. arctostaphylos berries in treating hypertension in overweight/obese patients.

Kianbakht S and Hashem-Dabaghian F (2019).
Complement Ther Med.
PubMed:
31126570

A randomised controlled trial of Lavender (Lavandula Angustifolia) and Lemon Balm (Melissa Officinalis) essential oils for the treatment of agitated behaviour in older people with and without dementia.

This study examines the effectiveness of Lavender and Lemon Balm essential oils in managing agitation in older people with and without dementia in residential care facilities.

Watson K, Hatcher D and Good A (2019).
Complement Ther Med.
PubMed:
30670268

Volatile Terpenes and Brain Function: Investigation of the Cognitive and Mood Effects of Mentha × Piperita L. Essential Oil with In Vitro Properties Relevant to Central Nervous System Function.

Essential oils from various plants in the Lamiaceae sub-family Nepetoideae have been shown to have cognitive and mood effects possibly related to their effects on neurotransmitters. Researchers conducted a double-blind, placebo-controlled study to assess the cognitive and mood effects of peppermint essential oil, which showed promising in vitro properties. The study involved 24 participants who consumed single doses of encapsulated placebo and peppermint essential oil. The highest dose of essential oil improved performance on the demanding Rapid Visual Information Processing task and attenuated fatigue, compared to the placebo. Peppermint oil also showed cholinergic inhibitory, calcium regulatory, and GABA/nicotinic receptor binding properties. Future studies should examine higher doses of peppermint essential oil.

Kennedy D et al (2018).
Nutrients.
PubMed:
30087294

Reducing antibiotic use for uncomplicated urinary tract infection in general practice by treatment with uva-ursi (REGATTA) - a double-blind, randomized, controlled comparative effectiveness trial.

Researchers investigated whether initial treatment with Arctostaphylos uva-ursi (bearberry extract) in women with UTI can reduce antibiotic use without increasing symptoms or complications.

Afshar K et al (2018).
BMC Complement Altern Med.
PubMed:
29970072

Momordica charantia Administration Improves Insulin Secretion in Type 2 Diabetes Mellitus.

In a clinical trial, patients with type 2 diabetes who took Momordica charantia saw improvements in glycemic control, insulin secretion, and insulin sensitivity. This suggests that M. charantia could be a beneficial treatment for diabetes.

Cortez-Navarrete M et al (2018).
J Med Food.
PubMed:
29431598

Efficacy of Aloe vera/ Plantago Major Gel in Diabetic Foot Ulcer: A Randomized Double-Blind Clinical Trial.

This study investigates the use of Aloe vera/Plantago major gel (Plantavera gel) in healing diabetic foot ulcers, a common and serious complication in diabetic patients. The results could potentially provide a new and effective alternative treatment option.

Najafian Y et al (2019).
Curr Drug Discov Technol.
PubMed:
29336265

Cinnamomum zeylanicum (Ceylon cinnamon) as a potential pharmaceutical agent for type-2 diabetes mellitus: study protocol for a randomized controlled trial.

This study investigates the potential anti-diabetic effects of Sri Lankan cinnamon extract in patients with type-2 diabetes, which has not been explored before.

Ranasinghe P et al (2017).
Trials.
PubMed:
28962661

Efficacy and Safety of Ashwagandha (Withania somnifera (L.) Dunal) Root Extract in Improving Memory and Cognitive Functions.

Researchers conducted a randomized, double-blind, placebo-controlled study to investigate the effects of ashwagandha on cognitive function in adults aged 35-85 years. The study consisted of 50 participants who received either 300 mg of ashwagandha or a placebo twice daily for 8 weeks. Cognitive function was measured using various tests. The study found that the ashwagandha group had significant improvement in tests related to executive function, attention, and information processing speed compared to the placebo group. No adverse effects were reported. These findings suggest that ashwagandha may have potential as a safe and effective supplement for improving cognitive function in older adults. However, larger and longer-term studies are needed to confirm these results.

Choudhary D, Bhattacharyya S and Bose S (2017).
J Diet Suppl.
PubMed:
28471731