Review

Molecular mechanisms underlying the potential neuroprotective effects of Trifolium pratense and its phytoestrogen-isoflavones in neurodegenerative disorders.

The review article discusses the potential neuroprotective properties of phytoestrogen-isoflavones present in Trifolium pratense (Red clover) for the treatment of neurodegenerative disorders. Studies have shown that Trifolium pratense contains more than 30 isoflavone compounds, including biochanin A, daidzein, formononetin, and genistein. These compounds have been found to exhibit therapeutic efficacy against different neurodegenerative disorders through molecular interactions with estrogenic receptors, anti-inflammatory, anti-oxidative, antiapoptotic, and autophagic inducing mechanisms. The review provides detailed molecular mechanisms and experimental key findings for the clinical use of Trifolium pratense-derived isoflavones for the treatment of neurodegenerative disorders.

Neuroscience Trifolium pratense
Al-Shami AS, Essawy AE and Elkader HAEA (2023).
Phytother Res.
DOI:
10.1002/ptr.7870
PubMed:
37195042

The traditional herb Polygonum hydropiper from China: a comprehensive review on phytochemistry, pharmacological activities and applications.

L. (Polygonaceae) (PH) is a traditional Chinese medicine used to treat various diseases. It has pungent flavor, mild drug properties, and mainly affects the stomach and large intestine channels.

Phytochemistry Polygonum hydropiper
Kong YD et al (2023).
Pharm Biol.
DOI:
10.1080/13880209.2023.2208639
PubMed:
37194713

Neuroprotective Effects of Black Pepper and Its Bioactive Compounds in Age-Related Neurological Disorders.

Age-related neurological disorders (ANDs) are multifactorial diseases whose risk increases with age, characterized by oxidative stress, impaired mitochondrial function, and neuronal cell death. Black pepper has many health benefits, including neuroprotective properties, due to its active compound piperine. Recent studies have shown that piperine effectively prevents AND symptoms by modulating cell survival signaling and death. Novel nanodelivery systems are being developed to improve the efficacy and bioavailability of black pepper in experimental models, including clinical trials. Black pepper and its active ingredients have therapeutic potential for ANDs.

Neuroscience Piper nigrum
Balakrishnan R et al (2023).
Aging Dis.
DOI:
10.14336/AD.2022.1022
PubMed:
37191428

The processing methods, phytochemistry and pharmacology of Gastrodia elata Bl.: A comprehensive review.

Gastrodia elata Bl. is a Chinese medicinal material with various chemical components. It has medicinal and edible value and is used for various diseases. Its composition and pharmacological activity are of scientific interest.

Phytochemistry Gastrodia elata
Su Z et al (2023).
J Ethnopharmacol.
DOI:
10.1016/j.jep.2023.116467
PubMed:
37187361

Plant Antimicrobial Peptides: Insights into Structure-Function Relationships for Practical Applications.

This review focuses on the structure-function relationships of antimicrobial peptides (AMPs) and their potential as drug candidates. It highlights the importance of identifying key amino acid residues and minimal active cores to improve AMPs' properties, efficacy, and production.

Antimicrobial Impatiens balsamina
Slezina MP and Odintsova TI (2023).
Curr Issues Mol Biol.
DOI:
10.3390/cimb45040239
PubMed:
37185763

Genomics and Transcriptomics Reveal Genetic Contribution to Population Diversity and Specific Traits in Coconut.

This review discusses how molecular biotechnological tools, such as molecular markers and next-generation sequencing, can improve genetic improvement efforts in coconut breeding programs and aid in understanding the coconut genome's structure. This information is crucial for producing high-yielding and disease-resilient coconuts.

Genetics Cocos nucifera
Yousefi K et al (2023).
Plants (Basel).
DOI:
10.3390/plants12091913
PubMed:
37176970

Molecular and Epigenetic Aspects of Opioid Receptors in Drug Addiction and Pain Management in Sport.

This study explores the harmful effects of opioids, their impact on addiction and overdose, and the involvement of the mesocorticolimbic dopaminergic circuitry. It also addresses the use of synthetic opioids in athletes and the potential for doping.

NeurosciencePain Papaver somniferum
Mazzeo F, Meccariello R and Guatteo E (2023).
Int J Mol Sci.
DOI:
10.3390/ijms24097831
PubMed:
37175536

Anti-COVID-19 Potential of Ellagic Acid and Polyphenols of Punica granatum L.

Pomegranate's polyphenols may inhibit SARS-CoV-2 and regulate immune responses. It has potential as a COVID-19 treatment and may help replenish antioxidants during recovery.

COVID-19 Punica granatum
Alexova R et al (2023).
Molecules.
DOI:
10.3390/molecules28093772
PubMed:
37175181
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