Antimicrobial Studies

Broad-spectrum antiviral activity of Spatholobus suberectus Dunn against SARS-CoV-2, SARS-CoV-1, H5N1, and other enveloped viruses.

Scientists have found that an extract of Spatholobus suberectus Dunn (SSP), a medicinal plant, has broad-spectrum antiviral properties against SARS-CoV-1 and 2, HIV-1, and H5N1. SSP effectively inhibits viral entry, with EC values ranging from 3.6 to 5.1 μg/ml. Pre-treatment of pseudovirus or target cells with SSP showed consistent inhibitory activities with the respective EC value of 2.3 or 2.1 μg/ml. SSP blocked both SARS-CoV-2 spike glycoprotein and the host ACE2 receptor without toxic behavior. This plant extract has promising potential to be developed as a drug candidate for preventing and treating COVID-19 and other emerging enveloped viruses.

Liu Q et al (2022).
Phytother Res.
PubMed:
35943221

Antiviral activity of medicinal plant-derived products against SARS-CoV-2.

Extracts and phytocompounds from medicinal plants have been shown to have antiviral activity against SARS-CoV-2. These plant products impede the virus from attaching to host cells and prevent its multiplication inside the cell. They also have an immunomodulatory effect by controlling the release of cytokines associated with SARS-CoV-2 infections. These findings demonstrate the potential of plant-based treatments for COVID-19.

de Oliveira JR et al (2022).
Exp Biol Med (Maywood).
PubMed:
35894129