Chemical Constituents and Antimicrobial Activity of a Ganoderma lucidum (Curtis.) P. Karst. Aqueous Ammonia Extract.
- Sánchez-Hernández E et al (2023).
- Plants (Basel).
- PubMed:
- 37375896
The Carob tree, also known as "L'Kharrûb" in Morocco, has been traditionally used for treating various ailments. To understand its properties, we analyzed the chemical composition of the ethanolic extract of carob leaves (CSEE) and conducted several tests. The CSEE extract, rich in phenolic acids and flavonoids, exhibited potent antioxidant activity, comparable to ascorbic acid. It also showed broad-spectrum antibacterial activity but moderate effectiveness against fungi. Additionally, the extract demonstrated dose-dependent inhibition of human breast cancer cell lines. At lower concentrations, it did not induce DNA damage, but a higher concentration showed genotoxic effects. Computational analysis predicted potential biological activities and evaluated the toxicity of the extract's constituents. This research provides valuable insights into the medicinal properties of the Carob tree.
This review highlights the antimicrobial potential of PlL extracts against oral biofilm-associated diseases. These extracts are more effective than other PlL derivates and could be useful in preventing and reversing intraoral dysbiosis. They can be incorporated into toothpaste, mouthwashes, and local delivery devices for clinical management.