Waste Citrus limon Leaves as Source of Essential Oil Rich in Limonene and Citral: Chemical Characterization, Antimicrobial and Antioxidant Properties, and Effects on Cancer Cell Viability.

This study explored the chemical composition, cytotoxicity, and antimicrobial and antioxidant activity of lemon leaf essential oil (LLEO) from plants in Sardinia, Italy. The main components of the LLEO were limonene, geranial, and neral. LLEO exhibited antimicrobial activity against various bacterial strains and yeasts. It also showed strong radical scavenging ability. In cell viability experiments, LLEO significantly reduced viability in cancer cells, while higher concentrations affected normal fibroblasts and keratinocytes. LLEO also displayed a pro-oxidant effect in cancer cells. This research highlights the potential benefits of lemon leaf essential oil for various applications in health and wellness.

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DOI:

10.3390/antiox12061238

PubMed:

37371968

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37367160

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