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J Med Food.

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10.1089/jmf.2023.K.0105

PubMed:

38442325

Inhibition of IL-17 signaling in macrophages underlies the anti-arthritic effects of halofuginone hydrobromide: Network pharmacology, molecular docking, and experimental validation.

HF, derived from Chinese herb, shows promise in treating RA with anti-inflammatory effects. Further research needed to understand how HF works to benefit RA patients.

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38413973

Xuetongsu attenuates bone destruction in collagen-induced arthritis mice by inhibiting osteoclast differentiation and promoting osteoclast apoptosis.

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Network analysis, in vivo, and in vitro experiments identified the mechanisms by which Piper longum L. [Piperaceae] alleviates cartilage destruction, joint inflammation, and arthritic pain.

Study evaluated the efficacy of L. [Piperaceae] in inhibiting pain and joint destruction in osteoarthritis (OA). Network analysis and molecular docking predicted potential targets and pathways. Results showed that L. [Piperaceae] may be a disease-modifying OA drug candidate.

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Front Pharmacol.

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38328576

Evaluation of the efficacy and safety of a herbal formulation for rheumatoid arthritis - A non-inferiority randomized controlled trial.

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J Ethnopharmacol.

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38316221

Efficacy and Mechanisms of Silybum Marianum, Silymarin, and Silibinin on Rheumatoid Arthritis and Osteoarthritis Symptoms: A Systematic Review.

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Curr Rheumatol Rev.

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38314596

Piperlongumine, a Piper longum-derived amide alkaloid, protects mice from ovariectomy-induced osteoporosis by inhibiting osteoclastogenesis via suppression of p38 and JNK signaling.

Luo N et al (2024).

Food Funct.

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10.1039/d3fo03830k

PubMed:

38311970

Natural compound library screening to identify berberine as a treatment for rheumatoid arthritis.

Zhang L et al (2024).

Clin Rheumatol.

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10.1007/s10067-024-06871-1

PubMed:

38305937