Brevilin A shows an anti-tumor role in prostate cancer via the lncRNA H19/miR-194/E2F3 signaling pathway.

Brevilin A, a natural compound, has been discovered to have anti-tumor properties in prostate cancer cells. In our study, we investigated the relationship between Brevilin A and the biological behaviors of these cells. We found that Brevilin A inhibited cell proliferation, migration, and invasion, and also promoted apoptosis. This was achieved by suppressing the expression of lncRNA H19 and E2F3, while increasing the level of miR-194. Furthermore, our experiments using a mouse model confirmed that Brevilin A had a tumor-repressing effect. Overall, Brevilin A shows promise as a potential treatment for prostate cancer.

You P et al (2023).

Aging (Albany NY).

DOI:

10.18632/aging.204744

PubMed:

37253635

Polyphyllin VII protects from breast cancer-induced osteolysis by suppressing osteoclastogenesis via c-Fos/NFATc1 signaling.

This study explores the potential of Polyphyllin VII (PP7), a compound derived from a traditional Chinese herb, in treating bone destruction caused by metastatic breast cancer. The researchers found that administering PP7 significantly reduced osteolysis induced by breast cancer cells in mice. PP7 also inhibited the formation of osteoclasts, reduced bone resorption, and promoted the formation of osteoblasts. The study suggests that PP7 has the potential to be a safe and effective treatment for preventing and treating bone destruction in breast cancer patients with bone metastases.

Yang Q et al (2023).

Int Immunopharmacol.

DOI:

10.1016/j.intimp.2023.110316

PubMed:

37253315

Citri Reticulatae Pericarpium-Reynoutria japonica Houtt. herb pair suppresses breast cancer liver metastasis by targeting ECM1-mediated cholesterol biosynthesis pathway.

A traditional Chinese herb pair, Citri Reticulatae Pericarpium-Reynoutria japonica Houtt. (CR), shows potential for treating liver metastasis in breast cancer patients. Liver metastasis is a significant problem in breast cancer, resulting in low survival rates and poor prognosis. This herbal treatment, used in clinics, may offer hope for improving outcomes and addressing cholesterol gallstone disease as well. Further research and clinical trials are needed to fully understand the effectiveness and mechanisms of this treatment option.

Wang J et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.154896

PubMed:

37247588

Effect of Annona squamosa leaf extract on human promyelocytic leukemia cells subjected to oxidative stress.

In this study, the researchers examined the impact of a specific plant extract on human promyelocytic leukemia cells. They wanted to determine if the extract could protect these cells from oxidative stress and damage. The results showed that the extract had antioxidative effects and could potentially offset damage caused by oxidative stress. This research is significant because it provides valuable insights into the potential therapeutic properties of the plant extract, specifically in relation to leukemia cells. By better understanding how this extract works, we can potentially develop more effective treatments for leukemia in the future.

Dilworth LL et al (2023).

J Complement Integr Med.

DOI:

10.1515/jcim-2023-0048

PubMed:

37247307

Combination Curcuma longa and Phyllanthus niruri Extract Potentiate Antiproliferative in Triple Negative Breast Cancer MDAMB-231 Cells.

Researchers investigated the effects of combining Curcuma longa extract (CL) and Phyllanthus niruri extract (PN) on the proliferation of triple negative breast cancer cells (TNBC). TNBC cells are highly metastatic and have the ability to renew themselves uncontrollably. CL and PN are known to have anti-proliferative effects on cancer cells. This study aims to determine if the combination of CL and PN can effectively inhibit TNBC cell proliferation. Understanding this could lead to potential treatment options for TNBC patients.

Hermansyah D et al (2023).

Asian Pac J Cancer Prev.

DOI:

10.31557/APJCP.2023.24.5.1495

PubMed:

37247268

Network meta-analysis of 8 types of traditional Chinese medicine injection combined with chemotherapy in colorectal cancer treatment.

Researchers compared 8 traditional Chinese medicine injections with chemotherapy for treating colorectal cancer, using network meta-analysis to find the best approach and enhance outcomes.

Gao W and Zhang K (2023).

J Cancer Res Clin Oncol.

DOI:

10.1007/s00432-023-04892-y

PubMed:

37246189

Herb Robert's Gift against Human Diseases: Anticancer and Antimicrobial Activity of Geranium robertianum L.

In this research, the phytochemical profile of a widely distributed plant, also used in traditional medicine, was assessed. The extracts from the plant showed significant anticancer activity and also demonstrated antiviral, antibacterial, and antifungal effects. The presence of organic and phenolic acids, hydrolysable tannins, and flavonoids was identified through phytochemical analysis. The extracts inhibited the development of a virus-induced cytopathic effect and reduced the viral load. Additionally, the extracts and fractions displayed versatile antibacterial activity, particularly against Gram-positive bacteria. These findings support the traditional use of this plant in treating hard-to-heal wounds.

Świątek Ł et al (2023).

Pharmaceutics.

DOI:

10.3390/pharmaceutics15051561

PubMed:

37242803

(1→3)-α-d-Glucooligosaccharides Increase the Killing Capacity of NK Cells against Selected Human Colon Cancer Cells.

Lemieszek MK et al (2023).

Molecules.

DOI:

10.3390/molecules28104212

PubMed:

37241952