Hibiscus extract reduces liver damage caused by anti-cancer drug cisplatin in rats and enhances its effectiveness in killing lung cancer cells.
Researchers reviewed 21 studies on herbal compounds for liver metastasis inhibition, finding Euphorbia kansui's potential in altering the tumor and liver microenvironments. This could guide future drug development against liver metastasis.
The 40% ethanol fraction (EF40) of the root extract possesses attractive anticancer properties with no toxicity to normal cells. EF40 reduces the expression of Nrf2, a protein found in many cancers, leading to the accumulation of reactive oxygen species (ROS) that cause cell cycle arrest and apoptosis. EF40 also inhibits NSCLC cell migration by downregulating MMPs and hnRNP-K. Mouse studies showed significant suppression of tumor growth and lung metastasis. EF40 could be a potential natural anti-NSCLC drug that requires further attention for its mechanisms and clinical applications.
Summary: In this study, we investigated the chemical composition and properties of leaf extracts from (Asteraceae), a plant traditionally used in folk medicine. We found that the extracts had high levels of phenols and flavonoids, and exhibited strong antioxidant activity. The extracts also showed dose-dependent cytotoxic effects on cancer cells and increased the number of apoptotic cells. Additionally, the extracts increased reactive oxygen species levels. Molecular docking identified two compounds with high binding affinities. This study highlights the potential health benefits of leaf extracts and suggests further research to identify the active compounds.
A herbal remedy called Paris polyphylla has been used for centuries to treat convulsions, head shaking, tongue fiddling, and epilepsy. Recent studies suggest that this remedy's ability to improve learning and memory may be due to specific polysaccharides found in the plant. These polysaccharides are thought to influence important signaling pathways involved in brain function. The findings also suggest that Paris polyphylla could have a protective effect on the nervous system. This research could have implications for the development of new treatments for neurological disorders.
Glabridin, a compound found in Glycyrrhiza glabra, has shown potential in the treatment of Triple-negative breast cancer (TNBC). In a mouse model, glabridin enhanced the effectiveness of the front-line therapy, paclitaxel, by reducing tumor burden and inhibiting the formation of lung nodules. It also reversed the traits of hostile cancer cells and promoted apoptosis in tumor tissue. Furthermore, glabridin improved the pharmacokinetics of paclitaxel by slowing down its metabolism in the liver. With its dual role in enhancing anti-metastatic activity and limiting tumorigenesis, glabridin shows promise as a potential neoadjuvant therapy for paclitaxel chemoresistance and cancer recurrence. Further research is needed to fully explore its potential.
In this study, we explore the potential of a commonly used Chinese herb called L. (TT) in treating liver cancer. While it has been historically used for breast cancer, its effects on liver cancer have not been extensively investigated. By examining its pharmacological activities, we aim to uncover its anti-liver cancer properties and understand the underlying mechanisms. This research holds significance as it may provide valuable insights into the potential of TT extract as a novel treatment option for liver cancer.