Cancer Studies

Proteomics Analysis of Polyphyllin D-Treated Triple-Negative Breast Cancer Cells Reveal the Anticancer Mechanisms of Polyphyllin D.

Polyphyllin D (PD) from Paris polyphylla herb exhibits anticancer effects in triple-negative breast cancer via apoptosis induction and alterations in spliceosome function. NOMO2/3 may be a potential target of PD. Further validation is required.

Wei C et al (2023).
Appl Biochem Biotechnol.
PubMed:
37624509

Evaluating Alterations of the Oral Microbiome and Its Link to Oral Cancer among Betel Quid Chewers: Prospecting Reversal through Probiotic Intervention.

The study examines the effects of betel quid consumption on oral health and cancer development. It highlights the dysbiosis caused by betel quid in the oral microbiota and suggests that restoring the microbiota could be a potential therapy for oral cancer.

Diwan P et al (2023).
Pathogens.
PubMed:
37623956

Moringa oleifera: A Review on the Antiproliferative Potential in Breast Cancer Cells.

This review highlights the potential of the medicinal tree (MO) in treating breast cancer. MO extract has shown antioxidant properties and ability to induce apoptosis in breast cancer cells, making it a potential alternative drug therapy.

Moremane MM, Abrahams B and Tiloke C (2023).
Curr Issues Mol Biol.
PubMed:
37623253

Tong-Xie-Yao-Fang promotes dendritic cells maturation and retards tumor growth in colorectal cancer mice with chronic restraint stress.

Researchers investigated the effect of Tong-Xie-Yao-Fang (TXYF), a traditional Chinese medicine formula, on colorectal cancer (CRC) accompanied by psychological stress. TXYF improved depression and reduced intestinal symptoms, suggesting its potential as an intervention for CRC patients with psychological stress.

Jiang Y et al (2023).
J Ethnopharmacol.
PubMed:
37619860

Brucea javanica oil inhibits tongue squamous cell invasion and metastasis by regulating miR-138-EZH2 pathway.

Brucea javanica oil (BJO) inhibits tongue squamous cell carcinoma (TSCC) invasion and metastasis by up-regulating miR-138 and down-regulating EZH2, Slug, p-ERK1/2, and Vimentin through the miR-138-EZH2 pathway. This suggests a potential therapeutic strategy for TSCC.

Jiang L et al (2023).
J Stomatol Oral Maxillofac Surg.
PubMed:
37619672

Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation.

Piper longum extract, specifically pipernonaline, shows potential as a new anti-austerity agent for pancreatic cancer treatment. It selectively kills cancer cells in low-nutrient conditions, inhibits cell migration, and targets the Akt/mTOR/autophagy pathway. Promising for future therapy.

Fujihashi Y et al (2023).
Chem Biodivers.
PubMed:
37612242

Charge Transfer Copper Chelating Complex and Biogenically Synthesized Copper Oxide Nanoparticles Using Salvia officinalis Laves Extract in Comparative Spectrofluorimetric Estimation of Anticancer Dabrafenib.

Scientists developed two spectrofluorimetric probes using ecologically synthesized copper oxide nanoparticles and a copper chelate complex to detect the anticancer drug Dabrafenib. The probes showed linear concentration ranges and low detection limits. Excipients and other substances had no effect on the detection.

Alterary SS et al (2023).
J Fluoresc.
PubMed:
37610703

Potential of Indonesian Herbal as an Anti-Cancer Therapy: A Systemic Review of in vitro Studies.

Researchers in Indonesia studied the use of natural ingredients from herbal plants as a potential therapy for cancer. With 6000 plant species used as herbal medicines in Indonesia, their findings could lead to effective treatments with fewer side effects.

Permatasanti A and Hidayat W (2023).
Cancer Manag Res.
PubMed:
37608914