Cancer Studies

Chebulinic Acid: An Incipient Anticancer Agent.

T. chebula and chebulinic acid have multiple medicinal properties, including antimicrobial, antioxidant, anti-inflammatory, and hepatoprotective effects. They have potential use in treating various diseases and may be beneficial for general health and disease prevention.

Aashima et al (2023).
Recent Pat Anticancer Drug Discov.
PubMed:
37605424

Integrating network pharmacology and experimental studies for uncovering the molecular mechanisms of Dioscorea bulbifera L. in the treatment of thyroid cancer.

HYZ, a traditional Chinese medicine, shows promise in treating thyroid cancer by improving symptoms and reducing tumor volume. However, the exact mechanism of HYZ's action is still unknown.

Liu Z et al (2023).
Heliyon.
PubMed:
37600377

Novel biogenic silver nanoconjugates of Abrus precatorius seed extracts and their antiproliferative and antiangiogenic efficacies.

Silver nanoconjugates derived from Abrus precatorius plants were synthesized and evaluated for their antiproliferative and antiangiogenic effects against cervical and oral carcinoma. They showed effective inhibition of cancer cells and reduced blood vessel growth, suggesting potential for tumor control.

Kaur A et al (2023).
Sci Rep.
PubMed:
37598190

Limonoids from neem (Azadirachta Indica A. Juss.) are potential anticancer drug candidates.

Neem tree extracts contain limonoids with potent medicinal properties. These compounds have been found to display anticancer effects by preventing cancer cell growth, inflammation, invasion, and drug resistance. Neem limonoids offer potential as natural compounds for cancer prevention and therapy.

Nagini S, Palrasu M and Bishayee A (2023).
Med Res Rev.
PubMed:
37589457

Hedyotis diffusa-Sculellaria barbata (HD-SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis.

Combination of Hedyotis diffusa and Scutellaria barbata inhibits colorectal cancer through downregulation of hsa_circ_0039933, a molecule that promotes cancer progression via the Wnt signaling pathway.

Zhu D, Yuan S and Chen C (2023).
Sci Rep.
PubMed:
37587207

Polysaccharide from Paris polyphylla improves learning and memory ability in D-galactose-induced aging model mice based on antioxidation, p19/p53/p21, and Wnt/β-catenin signaling pathways.

This study shows that Paris polyphylla polysaccharide component 1 (PPPm-1) can improve learning and memory in aging mice. It works by reducing oxidative stress, regulating the cholinergic nervous system, enhancing long-term memory, and activating the Wnt/β-catenin signaling pathway.

Sha A et al (2023).
Int J Biol Macromol.
PubMed:
37579895

Hypophyllanthin and Phyllanthin from Phyllanthus niruri Synergize Doxorubicin Anticancer Properties against Resistant Breast Cancer Cells.

Hypophyllanthin and phyllanthin from a plant enhance doxorubicin's effectiveness against breast cancer cells through various mechanisms, making them potential chemomodulators.

Abdel-Sattar OE et al (2023).
ACS Omega.
PubMed:
37576627